海南大学博士,44118太阳成城集团精神神经医学研究院讲师,硕士研究生导师,现从事蛋白质棕榈酰化修饰调控各类疾病发生发展的机制研究。主持国家自然科学基金青年科学基金项目:ZDHHC6介导的AEG-1棕榈酰化修饰调控肝细胞癌发生发展的机制研究;河南省科学技术厅外国专家项目:zDHHC1调控泡沫细胞形成及动脉粥样硬化进程的机制研究。近几年以第一作者在国际期刊Cellular & Molecular Immunology、Theranostics、Frontiers in immunology、Molecular Oncology发表文章6篇,并参与发表Science China Life Sciences、PLoS Pathogens、Frontiers in Cell and Developmental Biology等多篇SCI论文。
研究方向:蛋白质棕榈酰化修饰调控各类疾病发生发展的机制研究
代表成果:
一、发表的论文
1.Zhou Binhui, Zhang Mengjie, Ma Haoyuan, et al. Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases. Cell Mol Immunol. Published online May 8, 2024.
2. Binhui, Wang Ying, Zhang Lichen, et al. The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma. Theranostics. 2022;12(16):6898-6914.
3.Zhou Binhui, Lawrence Toby, Liang Yinming. The Role of Plasmacytoid Dendritic Cells in Cancers. Front Immunol. 2021;12:749190.
4.Zhou Binhui, Yang Wenyi, Li Wushan, et al. Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis. Front Immunol. 2021;11:607442.
5.Zhou Binhui, Hao Qianyun, Liang Yinming, Kong Eryan. Protein palmitoylation in cancer: molecular functions and therapeutic potential. Mol Oncol. 2023;17(1):3-26.
6.Yang Wenyi, Zhou Binhui, Liu Qi, et al. A Murine Point Mutation of Sgpl1 Skin Is Enriched With Vγ6 IL17-Producing Cell and Revealed With Hyperpigmentation After Imiquimod Treatment. Front Immunol. 2022;13:728455.
二、主持的课题:
1. 国家自然科学基金青年基金项目,ZDHHC6介导的AEG-1棕榈酰化修饰调控肝细胞癌发生发展的机制研究(32000491),2021.01-2023.12
2. 河南省科学技术厅外国专家项目,zDHHC1调控泡沫细胞形成及动脉粥样硬化进程的机制研究(HNGD2023023),2023.01-2023.12
招生方向:细胞生物学
导师邮箱:zhoubinhui@126.com