牛玉娜（1982.1-），理学博士，副教授，硕士生导师，从事自噬与感染免疫、NK细胞活性调节的研究，目前的主要研究方向：1.线粒体自噬在HTLV-1感染过程中作用及其机制研究；2.细胞自噬在白血病细胞耐药、白血病发生中的作用和机制研究；3. NK的活性调控的机制研究及新型NK细胞免疫疗法在治疗髓细胞白血病中的应用研究。
【受教育经历】
2000.09-2004.06，河南农业大学，动物科学，本科
2004.09-2007.06，华中科技大学，动物遗传学，硕士
2007.09-2010.06，中山大学，动物学，博士
【研究工作经历】
2015.01-2016.11 中国科学院上海生命科学研究院 博士后
2017.02-2017.08 美国杜克大学 博士后
2017.11-2021.03 44118太阳成城集团医学检验学院 讲师
2021.04-至今 44118太阳成城集团医学检验学院 副教授
2010.07-2011.07，华大基因研究院
2011.10-2014.09，苏州大学唐仲英医学研究院 助理研究员
2014.10-2020.04 44118太阳成城集团医学检验学院 讲师
2014.10-2020.04 44118太阳成城集团医学检验学院 副教授
【承担及完成国家级/省级课题】
1. 河南省自然科学基金：EVI1通过调控自噬参与白血病干细胞的干性维持，2017/01-2018/12, 10万元，项目编号162300410213，主持
2. 国家自然科学基金：BCL3通过STAT3调控NK细胞的功能和机制研究，2018/1/1-2020/12/30，20万元，项目编号81701554，主持
3. 河南省教育厅重点科研项目：河南省高等学校重点科研项目计划(项目编号: 21A310011)资助的课题，呼吸链解偶联剂CCCP抗HTLV-1病毒的作用机制研究, 2021/1/1-2022/12/30，3万元，项目编号21A310011，主持
【代表性论著】（#为第一作者，*为通讯作者）
1. Yuna Niu#, Xue Yang, Yifei Chen, Xinyue Jin, Li Li, Yilin Guo, Xuelu Li, Yecheng Xie, Yun Zhang, Hui Wang. EVI1 induces autophagy to promote drug resistance via regulation of ATG7 expression in leukemia cells.Carcinogenesis, 2020 ;41(7):961-971.
2. Yuna Niu#, Xue Yang, Yifei Chen, Linbo Zhang, Xinyue Jin, Youjing Tang, Li Li,Lu Yu, Yilin Guo, Hui Wang. BCL3 expression is a potential prognostic and predictive biomarker in acute myeloid leukemia of FAB Subtype M2. Pathol Oncol Res. 2019 ;25(2):541-548.
3. Yuna Niu#, Xue Yang,YifeiChen,XinyueJin, Yecheng Xie ,Youjing Tang,Li Li,ShiboLiu,YilinGuo,XueluLi,LiangweiDuan,HuiWang. Distinct prognostic values of Annexin family members expression in acute myeloid leukemia.Clin Transl Oncol.2019 ;21(9):1186-1196
4. Yuna Niu#, Qingqing Liu, Suping Zhang, Na Yuan, Yan Cao, Jinyang Cai, Weiwei Lin, Fei Xu, Zhen Wang, Jianrong Wang. Alternative messenger RNA splicing of autophagic gene Beclin 1 in human B-cell acute lymphoblastic leukemia cells. Asian Pac J Cancer Prev. 2014;15(5):2153-8.
5. Yuna Niu#, Delin Mo, Limei Qin, Chong Wang, Anning Li, Xiao Zhao, Xiaoying Wang, Shuqi Xiao, Qiwei Wang, Ying Xie, Zuyong He, Peiqing Cong, Yaosheng Chen*. Lipopolysaccharide-induced miR-1224 negatively regulates tumour necrosis factor-α gene expression by modulating Sp1. Immunology. 2011 ;133(1):8-20.
6. Liangwei Duan, Qianqian Zheng, Zhang H,Yuna Niu, Yunwei Lou, Wang Hui. The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens. Front Immunol. 2020 ;11:576622
7. Yunwei Lou, Han M, Liu H,Yuna Niu, Liang Y, Guo J, Zhang W, Wang H. Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection. Cell Mol Immunol. 2020 ; 17(10):1053-1062.
8. 谢业成,郭仪琳,李雪露,高静涛,张硕,段良伟,牛玉娜*.BCL3转录共激活因子的亚细胞定位研究.中国细胞生物学学报. 2021;43(08): 1574-1580.
9. 李莉,张艺博,张林波,汤友静,陈逸飞,关丫丫,牛玉娜*.BCL3基因敲除对线粒体呼吸作用及ATP合成的影响.中国细胞生物学学报, 2018; 40(4): 533-541.
10. 杨雪,谢业成,郭仪琳,李雪露刘奂弟,段良伟,牛玉娜*, HTLV-1病毒感染诱导宿主细胞线粒体损伤.中华微生物学和免疫学杂志, 2019;39(12): 898-903.
11. 张林波,牛玉娜,王辉.信号转导与转录激活因子和肿瘤微环境对自然杀伤细胞功能及免疫监视影响的研究进展.44118太阳成城集团学报,2017,;34(11), 1037-1039.
12. 汤友静,牛玉娜,王辉. Pink1/Parkin介导的线粒体自噬分子机制.中国细胞生物学学报, 2017;39(7), 939-946.
13. Yun Zhang, Wenqing Tan, Lin Zhang, Shuyou Shi,Yuna Niu, Xue Yang, Jinjuan Qiao, Hui Wang. Highly sensitive and selective colorimetric determination of Staphylococcus aureus via chicken anti-protein A IgY antibody. Analytical Methods, 2019 ;11(29): 3665-3670.
14. Zhijian Wang, Fei Xu, Na Yuan,Yuna Niu, Weiwei Lin, Yan Cao, Jinyang Cai, Lin Song, Xin Li, Yixuan Fang, Wenli Zhao, Shaoyan Hu, Suning Chen, Suping Zhang, Jianrong Wang. Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases. Leuk Res. 2014 ;38(8):940-7.
15. Suping Zhang,Yuna Niu, Na Yuan, Aihong Zhang, Dan Chao, Qiuping Xu, Lijun Wang, Xueguang Zhang, Wenli Zhao, Yun Zhao, Jianrong Wang. Role of autophagy in acute myeloid leukemia therapy. Chinese Journal of Cancer; 2013 ;32(3):130-5.
16. Limei Qin, Yaosheng Chen,Yuna Niu, Weiquan Chen, Qiwei Wang, Shuqi Xiao, Anning Li, Ying Xie, Jing Li, Xiao Zhao, Zuyong He, Delin Mo. A deep investigation into the adipogenesis mechanism: profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway. BMC Genomics. 2010;11:320.
17. Shuqi Xiao, Jianyu Jia, Delin Mo, Qiwei Wang, Limei Qin, Zuyong He, Xiao Zhao, Yuankai Huang, Anning Li, Jingwei Yu,Yuna Niu, Xiaohong Liu, Yaosheng Chen Y. Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing*. PLoS One. 2010 ;5(6):e11377.
18. Shuqi Xiao, Delin Mo, Qiwei Wang, Jianyu Jia, Limei Qin, Xiangchun Yu,Yuna Niu, Xiao Zhao, Xiaohong Liu, Yaosheng Chen. Aberrant host immune response induced by highly virulent PRRSV identified by digital gene expression tag profiling. BMC Genomics. 2020 ;11:544.
19. Xiao Zhao, Delin Mo, Anning Li, Wen Gong, Shuqi Xiao, Yue Zhang, Limei Qin,Yuna Niu, Yunxue Guo, Xiaohong Liu, Peiqing Cong, Zuyong He, Chong Wang, Jiaqi Li, Yaosheng Chen. Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness. PLoS One.2010 ; 6(5):e19774.
20. Anning Li, Yaosheng Chen, Xiao Zhao,Yuna Niu, Peiqing Cong, Zongwu Zhang, Weiquan Chen, Wei Jiang, Delin Mo. Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene. Mol Genet Genomics. Epub. 2010 ;284(3):185-95.
21. Zhisheng Zhang, Delin Mo, Peiqing Cong, Zuyong He, Fei Ling, Anning Li,Yuna Niu, Xiao Zhao, Chunyan Zhou, Yaosheng Chen. Molecular cloning, expression patterns and subcellular localization of porcine TMCO1 gene. Mol Biol Rep. 2010 ;37(3):1611-8.
